Sinteza i biološka svojstva nekih azo boja na bazi 3-cijano-6-hidroksi-4-metil-1-propil-2-piridona
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Apstrakt
Azo boje su najznačajnija grupa organskih sintetskih boja. Visoki molarni ekstencioni koeficijenti, koji karakterišu azo jedinjena, doprinose njihovoj širokoj upotrebi kako u tradicionalnom bojenju materijala, tako i sve većoj primeni u novijim tehnologijama kao što su optički materijali i solarne ćelije. Mnoga istraživanja pokazuju da azo boje dobijene iz heterocikličnih molekula imaju biološku aktivnost. Arilazo piridonske boje pripadaju klasi disperznih boja koje ispoljavaju antibakterijsku, antifungalnu, antikancerogenu i antioksidativnu aktivnost. U ovom radu sintetisane su tri azo boje polazeći iz 2-, 3– i 4-aminofenola i 3-cijano-6-hidroksi-4-metil-1-propil-2-piridona. Struktura jedinjenja potvrđena je ATR-FTIR, NMR i UV-Vis podacima. Antioksidsativna aktivnost jedinjenja ispitana je ABTS metodom. Fizičko-hemijski deskriptori i ADME parametari određeni su in silico pomoću SwissADME programa.
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Reference
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