In vitro određivanje antioksidativne aktivnosti halkona na bazi ferocena

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Objavljeno Aug 2, 2023
DOI: https://doi.org/10.24094/ptk.023.207

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Anita Lazić
Innovation Center of the Faculty of Technology and Metallurgy, Belgrade, Serbia
Luka Matović
Innovation Center of the Faculty of Technology and Metallurgy, Belgrade, Serbia
Jelena Lađarević
Faculty of Technology and Metallurgy, University of Belgrade, Belgrade, Serbia
Aleksandra Mašulović
Innovation Center of the Faculty of Technology and Metallurgy, Belgrade, Serbia
Kristina Gak Simić
Innovation Center of the Faculty of Technology and Metallurgy, Belgrade, Serbia
Nataša Valentić
Faculty of Technology and Metallurgy, University of Belgrade, Belgrade, Serbia

Apstrakt

Derivati ferocena su poznati antioksidansi, antiparazitici, antitumorni, antivirusni, antibakterijski i antifungalni agensi. Pored primene u medicinskoj hemiji, derivati ferocena su od izuzetnog značaja u sintetičkoj organskoj hemiji, naročito u katalizovanim asimetričnim sintezama. Primenjuju se i u elektrohemiji i hemiji polimera, kao aditivi u gorivima, kao hemosenzori u agrohemiji i biosenzori glukoze i aktivnih komponenata u molekularnoj elektronici. U cilju dizajniranja novih antioksidativnih agenasa, u ovom radu, sintetisano je pet ferocenilhalkona koji su u potpunosti strukturno okarakterisani određivanjem temperature toplenja, FT-IR, 1H i 13C NMR spektroskopskim metodama. Sintetisani halkoni međusobno se razlikuju prema vrsti i položaju supstituenta na fenil-grupi u položaju 1 linearnog nezasićenog karbonilnog sistema. Potencijalna antioksidativna aktivnost ovih jedinjenja procenjena je primenom ABTS (2,2'-azinobis-(3-etilbenzotiazolin-6-sulfonska kiselina) metode i određivanjem IC50 vrednosti najefikasnijih jedinjenja.

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Kako citirati
LAZIĆ, Anita et al. In vitro određivanje antioksidativne aktivnosti halkona na bazi ferocena. Zbornik Međunarodnog kongresa o procesnoj industriji – Procesing, [S.l.], v. 36, n. 1, p. 207-213, aug. 2023. Dostupno na: <https://izdanja.smeits.rs/index.php/ptk/article/view/6911>. Datum pristupa: 17 mar. 2025 doi: https://doi.org/10.24094/ptk.023.207.
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Broj časopisa
God. 36 Br. 1 (2023): 36. Međunarodni kongres o procesnoj industriji
Sekcija
Procesne tehnologije
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