In vitro određivanje antioksidativne aktivnosti halkona na bazi ferocena

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Anita Lazić Luka Matović Jelena Lađarević Aleksandra Mašulović Kristina Gak Simić Nataša Valentić

Apstrakt

Derivati ferocena su poznati antioksidansi, antiparazitici, antitumorni, antivirusni, antibakterijski i antifungalni agensi. Pored primene u medicinskoj hemiji, derivati ferocena su od izuzetnog značaja u sintetičkoj organskoj hemiji, naročito u katalizovanim asimetričnim sintezama. Primenjuju se i u elektrohemiji i hemiji polimera, kao aditivi u gorivima, kao hemosenzori u agrohemiji i biosenzori glukoze i aktivnih komponenata u molekularnoj elektronici. U cilju dizajniranja novih antioksidativnih agenasa, u ovom radu, sintetisano je pet ferocenilhalkona koji su u potpunosti strukturno okarakterisani određivanjem temperature toplenja, FT-IR, 1H i 13C NMR spektroskopskim metodama. Sintetisani halkoni međusobno se razlikuju prema vrsti i položaju supstituenta na fenil-grupi u položaju 1 linearnog nezasićenog karbonilnog sistema. Potencijalna antioksidativna aktivnost ovih jedinjenja procenjena je primenom ABTS (2,2'-azinobis-(3-etilbenzotiazolin-6-sulfonska kiselina) metode i određivanjem IC50 vrednosti najefikasnijih jedinjenja.

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Kako citirati
LAZIĆ, Anita et al. In vitro određivanje antioksidativne aktivnosti halkona na bazi ferocena. Zbornik Međunarodnog kongresa o procesnoj industriji – Procesing, [S.l.], v. 36, n. 1, p. 207-213, aug. 2023. Dostupno na: <https://izdanja.smeits.rs/index.php/ptk/article/view/6911>. Datum pristupa: 26 feb. 2024 doi: https://doi.org/10.24094/ptk.023.207.
Sekcija
Procesne tehnologije

Reference

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